ASXL1 gene plays an important role in Bohring-Opitz syndrome


Recently, key laboratory researcher Wang Qianfei from Beijing Institute of Genomics, Chinese Academy of Medical accurate genome and professor Yang Fengchun of the University of Miami Miller School of Medicine cooperated to reveal the critical role of germline newborn Bohring-Opitz syndrome mutations ASXL1 multipotent progenitor cells in the bone marrow stromal function bone development and maintenance, and the research was published in the journal Stem Cell Reports. There are also some other studies about recombinant proteins that were published in the famous journal.

Bone marrow stromal multipotent progenitor cell (BMSC) is a kind of multipotent progenitor cells with self-renewal and multi-lineage differentiation potential. The relationship between ostosis and fat cells in BMSC is crucial for normal bone homeostasis and the differentiation fate of these cells causes the abnormalities of body. Bohring-Opitz syndrome (BOS) is heterogeneity of genetic disease which causes death of young children, and it is characterized by severe…

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